Dear Colleague,

In previous emails we provided resources on the fundamentals of tissue clearing and discussed various approaches and methods. In this and upcoming emails we will present case studies to show how powerful the combination of tissue clearing and light sheet microscopy can be across a range of research areas.

Our first case study applies these techniques to cancer metastasis research and preclinical drug development. Metastases are a leading cause of cancer related deaths and are therefore an important target in anti-cancer therapies. 

To be successful, these treatments need to be able to target multiple metastases through the body. Current preclinical whole animal imaging modalities such as magnetic resonance and bioluminescence lack the sensitivity and resolution needed to determine if therapeutic candidates are effective at targeting these metastases.

In a recent study in the laboratory of Dr. Ali Erturk, whole mouse clearing and light sheet fluorescence imaging were combined with deep learning technology in order to identify and monitor the development of new tumors including micro metastases throughout the entire mouse body. Discover more about how they performed whole mouse clearing and imaging and the deep learning technology they developed here.

You can hear directly from Dr. Ali Ertürk about this research and be inspired by his unique view on how science can learn from art in a short interview here.

Kind regards,

Byron Hartman
Microscopy Product Manager at Miltenyi Biotec

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